BDBM50276074 CHEMBL470791::HDAC inhibitor, Compound 2::N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(1-oxo-2,7-diazaspiro[3.5]nonan-7-yl)nicotinamide

SMILES Nc1ccc(cc1NC(=O)c1ccc(nc1)N1CCC2(CNC2=O)CC1)-c1cccs1

InChI Key InChIKey=BHUJWKLXOJFZOZ-UHFFFAOYSA-N

Data  1 KI  11 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50276074   

TargetHistone deacetylase 2(Homo sapiens (Human))
Genentech

LigandPNGBDBM50276074(CHEMBL470791 | HDAC inhibitor, Compound 2 | N-(2-a...)
Affinity DataIC50:  53.8nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Genentech

LigandPNGBDBM50276074(CHEMBL470791 | HDAC inhibitor, Compound 2 | N-(2-a...)
Affinity DataKd:  48.1nMpH: 8.0Assay Description:Specifically, the experiments were conducted in black 384-well polypropylene plates (Corning Glass) in a 15-ul reaction volume consisting of 11 nM HD...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed